Bone Marrow Stem Cells - Mesenchymal Stem Cells

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Bone Marrow Stem Cells - Mesenchymal Stem Cells (MSCs)

 Medical Research is clear, Bone Marrow Stem Cells are a rich source of Mesechymal Stem Cells. These cells have shown significant regenerative capabilities, particularly in orthopedic tissues, muscle tissues, and tendons.

Tampa Bay and Louisville Kentucky Bone Marrow Stem Cell MSC Chart.
Click Human Stem Cells Comparison Chart to Enlarge.

Bone Marrow Stem Cells: Their Makeup

Research evidence suggests, that in addition to hematopoietic stem cells, bone marrow also contains endothelial stem cells, mesenchymal stem cells, multi-potential adult progenitor cells, pluripotent stem cells as well as (more generally)  tissue committed stem cells.  Many of these cells get released into the peripheral blood after normal tissue injury to regenerate damaged tissues. This is another important reason why medicine must consider stem cells from bone marrow for many cellular-based regenerative therapies, and not interpret bone marrow as just simply hematopoietic in nature.

Mesenchymal Stem Cells work by signaling the body to regenerate itself. The exciting part about how MSCs work, is not just their ability to become and replace different tissues and cells, but, rather, in their capacity to produce trophic factors, which are bio-active molecules that regenerate tissues, along with the bio-immunity functions to prevent infection. This is how the body was designed to heal and regenerate. Stem cell therapy essentially entails isolating and concentrating these cells, and and then reintroducing them back into the body so they can do their medicinal signaling work.

Bone Marrow Stem Cells: Continued

Recently by employing multiparameter sorting, researchers identified in murine bone marrow a homogenous population of rare (B0.02% of BMMNC) Sca-1 þ linCD45 cells that express by RQ-PCR markers of non-hematopoietic tissue-committed stem cells. These rare cells were able to grow cultures in vitro into neurospheres. In their study, they provide direct evidence that sorted from Bone Marrow Sca-1 þ linCD45 cells have the morphology and express several markers of undifferentiated embryonic-like stem cells and these cultures may differentiate into cells from all three germ-layers. The researchers hypothesize that this population of very small embryonic-like stem cells is more than likely deposited early in development in Bone Marrow, so perhaps these these cells can be automatically deployed by the body for normal tissue/organ regeneration (Ref: M Kucia, et. al. 2006).

Bone Marrow Stem Cells: The Amazing Regenerative Capacity of Living Things

Stem Cells are known for their remarkable ability to develop into different types of cells and tissue types in the human body. One of the best ways at understanding this regenerative capability, is to look no further than to the everyday salamander. A salamander is an amphibian capable of regenerating lost limbs, as well as other damaged parts of its body. It is now better understood that its regenerative capacity is due to cellular activity related to stem cells. More specifically, mesenchymal stem cell activity, (MSCs).

Up until recently, it was believed that this regenerative capacity was only limited to a few select living creatures like the salamander. However, new evidence and clever science is making it abundantly clear that higher-order living creatures, including human beings, actually posses the regenerative capacity to regenerate damaged tissue more completely than once believed.

The scientific community is moving ever closer to harnessing the capacity to exploit the amazing regenerative capacity of mesenchymal stem cell activity.

VIDEO Case in point. Man regrows finger tip in Ohio, and a second case of a woman regrowing finger tip in California. Each exploiting new Stem Cell Regenerative Medical Technology.

For bone marrow stem cell therapy, we use the Harvest SmartPrep Technology. The device is one of only a handful of technologies approved for in clinic procedures for stem cell therapy in the United States. The technology has been well documented in several research studies and is considered one of the better designed technologies for clinical Platelet-rich Plasma and Stem Cell Regenerative Therapies.


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