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HGH Injections – Optimal Dosing of HGH Replacement
HGH Injections and proper dosages have long been considered an important part of proper compliance for growth hormone replacement therapy. Unlike testosterone and other injectable therapies, HGH must be injected frequently, usually once daily. Doctors will differ on the number of HGH injections days per week, but at present, the consensus is 5-daily injections per week, with two days off.
HGH Injections – What’s the Difference between 191 AA HGH and 192 AA HGH?
Another concern related to HGH Injections and Dosages relates to the type of molecular structure of HGH. Originally, dating back to 1958, HGH was 100% bioidentical, but it was harvested from cadavers. Obtaining HGH from cadavers was obviously very labor intensive and time-consuming. It also posed the risk of spreading diseases from the host. Eventually, genetic engineering allowed for mass production of (synthetic) HGH in the laboratory around 1985. Soon thereafter, HGH prescriptions were all of the synthetic type and it was no longer harvested from cadavers.
When it was discovered HGH could be mass-produced through genetic engineering, the first synthetic versions of the medication were 192 amino acid (AA) HGH. Natural HGH circulating in our bodies consists of 191 amino acids (AA). However, in the 1980s, the technology wasn’t perfected enough for manufacturing true 100 % bioidentical synthetic HGH. The 192 AA HGH did work but came with the risk of the body rejecting a part of it as foreign. That is, in many instances, depending on the length of time used, eventually, the 192 AA HGH would cause the body to began developing antibodies (a resistant reaction to the effect of HGH). Over time, once antibodies are created, the body begins developing a tolerance to the HGH, reducing its efficacy.
Watch our doctor explain the Norditropin HGH Pen. Click button above to see video. See both Norditropin Nordilet and FlexPro Pen Versions, including dosage charts.
By the mid-1990s, most HGH manufacturers in the industrialized world improved lab technology to a level that permitted 100% bioidentical HGH of 191AA was reproducible. The risk of developing antibodies (resistance) from 191AA HGH is virtually none.
The only main concern with 192AA HGH in the modern era usually is when it is purchased as a generic on the black market, like from some unknown sources overseas. Why? Well, 192AA HGH is much less costly to produce, so generics and bootleg versions of HGH are more than likely to be made of the 192AA variety, and not the 100% molecular equivalent HGH circulating within the body.
HGH Injections – Normal consensus calls for 5 days of injections with 2 days off.
Now most physicians prescribe HGH injections for replacement therapy as follows:
- A daily dosage of 1 or 2 IUs per injection.
- Injected in the late evening to mimic the body’s natural growth hormone secretion cycle.
- Injected 5 days per week, with two days off.
Research suggests, for adults being treated with HGH replacement therapy, this may not necessarily be the most effective protocol. In fact, an argument can be made that injecting HGH 5 or more days per week may reduce some of its benefits.
In 1994, a Korean study looked at 28 patients over a 12-month period. All participants selected for the study were adults with human growth hormone deficiency. Each subject had been diagnosed after 20-years of age. The study separated the participants into three groups:
- Group 1: They were given HGH Injections 3-days per week.
- Group 2: They were given HGH Injections 7-days per week.
- Group 3: This group was given a placebo.
The dosages given to the two non-placebo groups were as follows:
- Group 1 / 3-Day: 0.18 units/kg/week. (Approx. 4 IU per Injection).
- Group 2 / 7-Day: 0,42 units/kg/week. (Approx. 4 IU per injection).
Blood exams were taken frequently to monitor HGH levels, lipids, and other biomarkers. The results of the study were surprising, as in many biometrics tracked, the 3-day HGH injection group saw more benefit. The key results break out as follows:
Weight: In all three groups, the body weight remained virtually the same.
Lean Body Mass: The 3-day HGH injection group added 2.8kg of lean muscle mass. The 7-day HGH injection group added 2.9kg of lean muscle mass. Not a significant difference.
Body Fat Reduction: The 3-Day HGH Injection group saw a 1.5% reduction in body fat, while the 7-day HGH injection group saw 2.8% reduction in body fat. This seems to be the one metric where injecting HGH 7-days per week benefits you over injection 3-days per week. See discussion below.
Lean Thigh Mass: The 3-day HGH injection group saw more increased muscle mass in their thighs, while both the 7-day HGH injection group and the placebo group saw no measurable increase. For men, this may be of interest, since larger thigh muscle mass is often associated with higher serum testosterone levels.
Exercise Capacity: The 3-day HGH Injection group saw increased exercise capacity over the 7-day HGH injection group and the placebo group.
Bone Mineral Density: No group saw an increase in bone mineral density. However, since the study was a relatively short 12-month study, it’s not significant. HGH use has been shown to increase bone mineral density in other studies of longer length and with 191AA HGH.
Cholesterol / Lipid Profiles: None of the groups saw any significant improvement in cholesterol and other lipids. However, this study was done in Korea using the Korean population. Their diet is much different than the Standard American Diet (SAD), and other western culture diets, so more than likely their cholesterol levels and lipids were already relatively good, so not a lot of improvement could be made anyway.
Discussion on HGH Injection Frequency and Dosage
As the 1994 study shows us, when it comes to HGH injections, more is not necessarily better. In fact, it may impede athletic performance. Although more investigation is required, it is possible that too high a dose too frequently injection may produce a limited amount of HGH resistance. It’s very natural for the body to block high levels of any physiological event. We know this from a growing number of insulin-resistant pre-diabetes epidemic we now see unfolding in modern society due to frequent over-feeding, creating high levels of hyperinsulinemia.
The one major difference between the two groups was in body fat reduction. The 7-dau HGH injection group saw 2.8% decrease in body fat, whereby the 3-day HGH injection group only saw a 1.5% reduction. Besides this difference, those on a limited budget may find injecting HGH 3 – 4 days a week will save you money and will save you money. For those concerned about the fat loss component, you can work with one of our practitioners on the HCG Diet or HCG Fast Diet program.
DOWNLOAD STUDY [PDF Thrice Weekly HGH Study]
HGH Injections in Children Dosages and IGF-1 Axis
In other studies, higher doses of HGH have been shown to increase idiopathic short stature (ISS) in children. One such study done in 1988, investigated 223 patients divided into three groups.
Group 1: 3 IUs per day, 6-days per week.
Group 2: 4.5 IUs per day, 6-days per week.
Group 3: 3 IUs per day, 6-days per week for year 1, then 4.5 IUs per day, 6-days per week thereafter.
Growth was compared among the three groups.
Year 1: Height velocity doubled in the 4.5 IU per day group over the 3 IU per day group. In the second year, height velocity no longer changed among the groups, as they were all taking similar dosages at that stage. Other similar studies have been done in children and generally, show similar results.
The conclusions of the study stated the following: During 4 years of rhGH therapy, growth and final height prognosis improved, slightly more with 4.5 IU/m2 than with 3 IU/m2 or 3 to 4.5 IU/m2. However, bone age advanced on average 4.8 years during this period; therefore, any effect on final height will probably be modest.
Because of studies such as these which were done with children, many physicians and practitioners still think higher IUs mean better results. However, differences between children’s studies and the adult human growth hormone study done in Korea give us clues to why children may benefit from higher dosages for short-duration use versus adults. It likely due to the higher IGF-1 Axis and its growing impact in bones.
When growth hormone increases combined with high protein diets, IGF-1 increases from growth hormone metabolized in the liver, but also from high protein metabolism. However, other research suggests that IGF-1 may be pro-cancer and pro-aging in adults, while lower IGF-1 may be of benefit for aging adults. Since children’s bones are growing, they benefit most from the IGF-1 conversion, while adults may benefit less from it.
It’s important to note that adults with HGH deficiency can benefit significantly from HGH replacement therapy. However, if too much concentration is placed on IGF-1 increases, then many can be missing the point in gaining maximum benefit from their therapy. In addition, HGH is the most expensive form of hormone replacement therapy.
Properly dosing to maximize benefit, is why patients should choose the right anti-aging medical group to support them in their treatment. Minimizing cancer risk is important by monitoring IGF-1 levels, diet and nutrition, and ensuring proper doses improve lean muscle mass, blood lipids, energy and other benefits as to be expected with HGH replacement therapy.
For those concerned mostly about managing fat loss. That is accelerated with the HCG Fast Diet program. It’s an intensive medically supervised weight-loss program using HCG, structured nutrition planning around macro-nutrients and incorporates fasting – like intermittent fasting and fasting-mimicking dieting. It’s more than just a normal diet, it’s a metabolic reboot focusing on accelerating fat-loss using nutritional ketosis along with the HCG medication.
Get more information and speak with one of our age management experts on how we can structure an affordable program that works best for you and your budget.
Traveling and Storage with Norditropin HGH
According to the Norditropin website, all Norditropin products must be refrigerated (36°F to 46°F) prior to first use.
Do not freeze and avoid direct light.
After the first injection, the pens can either be stored outside of the refrigerator (up to 77°F) for use for 21 days.
If stored in the refrigerator after first use the Norditropen HGH pen will last for 4 weeks. The temperature range should be between 36°F and 46°F.
Never place your pens in a freezer.