EXOSOMES: WHAT ARE THEY?
Exosomes are rapidly gaining momentum as a new and easier strategy for cellular regeneration.
The anti-inflammatory properties of exosomes aid in the healing.
Exosomes offer anti-fibrotic characteristics which can reduce the amount of scarring during wound repair.
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Exosomes: What are Exosomes?
Exosomes are the next frontier in regenerative cellular therapy. They are the extracellular vesicles that foster cell-to-cell communication and regeneration.
Exosomes: Gaining in Popularity in Regenerative Medicine
Exosomes are now considered to be the workhorses delivering the benefits of cell therapies like PRP and Stem Cells. Exosomes promote regeneration, influence growth of target cells, aid healing with anti-inflammatory properties, and contribute to cell fate decision.
The Promise of Exosomes - Video Series
Part 1: What Are Exosomes?
Part 2: History of Exosomes?
Part 3: Exosomes and Cancer Research
Part 4: Science & Exosomes?
Part 5: Collaboration with Research
Part 6: What's Next for Research?
Exosomes: How they work for regenerative health.
For years researchers and scientists believed stem cells worked by replacing damaged or diseased cells and differentiating into the respective cell type. This is essentially what occurs during a bone marrow transplant. Donor cells are harvested and transplanted into a patient to support the patient’s immune system.
Exosomes: The Paracrine Effect
More recently it is recognized that much of the regenerative outcomes observed from modern stem cell transplants, are actually due to what is known as a paracrine effect. The paracrine effect occurs when donor cells (or exosome molecules) secrete biological co-factors that signal to a patient’s own cells to modify their behavior for regeneration. That is, donor cells secrete biological factors that enlist the help of other cells and encourage neighboring cells to produce and secrete additional growth & repair factors for tissue regeneration.
Exosomes are important mediators in this process. Exosomes are extra-cellular vesicles which play important regenerative roles in intercellular communication. They in fact do a lot of the heavy lifting in tissue and cell regeneration, which is why many researchers are choosing to go straight to the “magic juice” (exosomes) and bypassing some of the more complicated and expensive handling necessary with the use of living stem cells. The hope is this will drive down the cost of treatment while also enhancing efficacy and quality of care.
Exosomes and their Potential Anti-Inflammatory Role
From a regenerative standpoint, exosomes work similarly to stem cells. In fact, some argue that it is the exosome micro-RNA molecular actions that play a key role in cellular regeneration.
As it has been documented in the study of both stem cells and exosomes, they can be beneficial for modulating inflammation. This occurs by down-regulating proteins that can develop into autoimmune activity.
Exosomes and their Potential Immunomodulatory Benefits
Like stem cells, exosomes appear to offer many of the comparable benefits as stem cells without being a stem cell. Exosomes are the extracellular vesicles. The molecules or proteins that act as messenger transports between cells.
They show great potential in regulating immune system activity, which can be significant for the leading autoimmune diseases like:
- Rheumatoid arthritis.
- The systemic lupus erythematosus (lupus).
- Inflammatory bowel disease (IBD).
- Multiple sclerosis (MS)
- Type 1 diabetes mellitus.
- Guillain-Barre syndrome.
- Chronic inflammatory demyelinating polyneuropathy.
The potential of exosomes in chronic and degenerative conditions is evolving. The hope is that eventually, exosomes will completely displace stem cell therapy for many conditions, making it much easier to apply point-of-care regenerative medicine.
FAQ Exosomes 1.00
Exosomes are nano-sized vesicles released by all cell types. Their size 30-to-150 nm They are containers that transport proteins, growth and anti-inflammatory factors and messages between cells.
Many researchers believe that Exosomes derived from young and health Mesenchymal Stem Cells (MSCs) can treat virtually all the same disordered treated in research by stem cells.
Exosomes may be the future of stem cell therapies. They are the messengers.
The science is evolving, but due to the science, exosome therapy may displace many stem cell therapies in the near future.
Exosome research suggests that one of the primary modes of action is the paracrine effect.
The Exosomes are inherently messengers that secrete biological co-factors that signal existing cells to modify their behavior for regeneration.
Exosomes may offer the same benefit as stem cells for many treatments. But they are not a cell.
The biological co-factors can aid with immuno-modulatory regulation of T-cells, B-cells and immuno-modulatory actions.
They can support vasculargenic, neurogenesis, cell repair, stimulate growth factors, and moderate inflammation in support of tissue regeneration.
That will depend on how the exosomes were derived, quality of the lab, and type of treatment. Therapies will typically range from $5,000 to $20,000 depending on the procedure.
Exosomes are delivered via local injection into joints, IV therapy, intranasel, and intrathecal.
These procedures are not approved by the FDA in the United States. If provided, they would be considered an off-label procedure.
Internationally, stem cell therapy and exosome therapies are growing in popularity.