EXOSOMES: WHAT ARE THEY?
Exosomes are rapidly gaining momentum as a new and easier strategy for cellular regeneration.
The anti-inflammatory properties of exosomes aid in the healing.
Exosomes offer anti-fibrotic characteristics which can reduce the amount of scarring during wound repair.
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Exosomes: What are Exosomes?
Exosomes are the next frontier in regenerative cellular therapy. They are the extracellular vesicles that foster cell-to-cell communication and regeneration.
Exosomes are now considered to be the workhorses delivering the benefits of cell therapies like PRP and Stem Cells. Exosomes promote regeneration, influence growth of target cells, aid healing with anti-inflammatory properties, and contribute to cell fate decision.
The Promise of Exosomes - Video Series
Exosomes: How they work for regenerative health.
For years researchers and scientists believed stem cells worked by replacing damaged or diseased cells and differentiating into the respective cell type. This is essentially what occurs during a bone marrow transplant. Donor cells are harvested and transplanted into a patient to support the patient’s immune system.
Exosomes: The Paracrine Effect
More recently it is recognized that much of the regenerative outcomes observed from modern stem cell transplants, are actually due to what is known as a paracrine effect. The paracrine effect occurs when donor cells (or exosome molecules) secrete biological co-factors that signal to a patient’s own cells to modify their behavior for regeneration. That is, donor cells secrete biological factors that enlist the help of other cells and encourage neighboring cells to produce and secrete additional growth & repair factors for tissue regeneration.
Exosomes are important mediators in this process. Exosomes are extra-cellular vesicles which play important regenerative roles in intercellular communication. They in fact do a lot of the heavy lifting in tissue and cell regeneration, which is why many researchers are choosing to go straight to the “magic juice” (exosomes) and bypassing some of the more complicated and expensive handling necessary with the use of living stem cells. The hope is this will drive down the cost of treatment while also enhancing efficacy and quality of care.